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Gut Vascular Axis
Steve Irsfeld RPh • November 13, 2024

Have you ever heard of this concept?

Gut Vascular Axis


Today will be another topic discussed at the conference my staff and I attended a couple of weeks ago.    We have all heard about the gut/brain connection and how a healthy gut is essential for what is going on in the brain, but did you know there is a direct correlation between the health of our gut and its effect on the cardiovascular system?    I didn't know it either, but as we get into the weeds on the gut/vascular axis, it will become evident as I unfold the different aspects of this topic.


Before we dive in, I would like to update you on the Function Health panel I talked about several weeks ago.    The panel is the 100+ tests for $499 through a company called Function Health.    The company has contracted with Quest Diagnostics to administer the tests at their sites, and if you go to the website, you can find independently owned labs that fall under the Quest Diagnostics umbrella.    Unfortunately, these independently owned labs are not contracted to draw the Functional Health labs.    There are no Quest Diagnostic labs in ND or SD; the closest is Billings, MT, going west, or Minneapolis, MN, going east.    This is unfortunate as the test is quite amazing, so if you are considering this test, you will have to travel to get it done.    I will keep you posted on the results of my follow-up labs. 


The gut-vascular axis is an area of research that explores how the health of our gut impacts our blood vessels and overall cardiovascular health.    Scientists have discovered that specific chemicals produced by the gut can affect blood vessels, leading to increased or decreased risk of diseases like heart disease.    Two of the most studied molecules related to the gut-vascular axis are short-chain fatty acids (SCFAs) and lipopolysaccharides (LPS).    Let's look at how each of these influences the gut-vascular axis.

SCFAs are molecules gut bacteria produce when they break down fiber from our food.    The most common SCFAs are acetate, propionate, and butyrate.    These SCFAs play essential roles in maintaining gut health, as they serve as an energy source for the cells lining the intestines and help keep the gut barrier strong.    However, SCFAs don't just stay in the gut; they can enter the bloodstream and impact blood vessels.


When SCFAs reach the blood, they help reduce inflammation and regulate blood pressure.    High blood pressure has been associated with decreased intestinal microbial diversity and SCFA-producing bacteria.    It has also been observed that high blood pressure is more pronounced with increased intestinal permeability (leaky gut), fibrosis, and decreased villous length of the small intestine.


Inflammation is a key factor in cardiovascular diseases, so SCFAs benefit vascular health.    SCFAs also influence the immune system, keeping it balanced and reducing the risk of chronic inflammatory conditions.    A high-fiber diet rich in vegetables, fruits, and whole grains encourages the production of SCFAs and promotes heart health.


When diet cannot fulfill the needs of the gut, it may be time to look at supplementation to aid the process.    Cranberry extract has many excellent properties, including increasing the microbiome's diversity with an increase in Akkermansia, bifidobacterium, and butyrate-producing bacteria.    In one study, 28 patients received a daily dose of 109mg of polyphenols from cranberry extract, equivalent to 60 grams of fresh cranberries, and within 4 days, there was significant improvement in the bacterial diversity of the gut.    Who says cranberries are for Thanksgiving only?


I have written about LPSs several times, so this should be a review for most readers.    LPS are molecules found in the outer membrane of certain bacteria, with the highest concentration in the gut.    If the gut barrier becomes "leaky" due to a poor diet, stress, infection, alcohol consumption, overeating, smoking, or other factors, LPS can escape into the bloodstream.    Once in the blood, LPS triggers an immune response that causes inflammation.    Chronic inflammation from LPS has been linked to high blood pressure, atherosclerosis (hardening of the arteries), and other cardiovascular diseases.

Finding out if you have LPS in the blood can be done with a gut barrier test done with a blood draw, or a simple fingerstick blood test.    The test looks for immunoglobulins that have formed for LPS, ocludin, and zonulin, indicating these markers are now in the blood.    If they show up in the blood, the lining of your gut has been compromised, and you will have a leaky gut.

Maintaining a healthy gut can reduce LPS levels. Eating a balanced diet with plenty of fiber and reducing stress can help keep the gut barrier strong, preventing LPS from leaking into the bloodstream and triggering inflammation.


Taking supplements can enhance the lifestyle modifications listed above, with a focus on probiotics, prebiotics, and polyphenols. Each of these three supplements has great benefits for gut health, but the real benefit can come into play when you dial down to specific ingredients.   Nutridyn’s Ultrabiotic Prebiotic checks many of the boxes necessary to lower LPS levels.  The combination of red wine polyphenols, organic gold kiwi, xylooligosaccharides, pomegranate and cherry extracts all working together to lower LPS by boosting targeted probiotics while increasing SCFAs.


The gut-vascular axis shows us how gut health directly impacts blood vessel health.    Maintaining a balanced diet rich in fiber, reducing intake of red meat and animal products, and adding targeted nutrients can help promote a healthy gut and protect our cardiovascular system.    It is an exciting time as scientists drill down on specific nutrients that target the gut-vascular axis, looking to prevent and manage heart disease.


You may be tired of me quoting Hippocrates but this is clearly another example of one of his quotes that "all disease begins in the gut".    The time to take care of our gut has never been more critical as we are continually bombed with toxins from our environment, and having a healthy gut goes so far in helping our overall health.    I apologize if things got a little technical today, but sometimes, it's important to dig deep into some of these topics.


Stop by or call the pharmacy for more information on the gut/vascular connection or targeted nutrients to support this connection.    Please visit my website at www.irsfeldpharmacy.com to find this and other archived articles in the blog section.   



Until next time, be vigilant about your health!!


By Steve Irsfeld RPh December 18, 2024
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By Steve Irsfeld RPh December 4, 2024
Season Affective Disorder I was wandering around the pharmacy today, trying to develop a topic for today’s article. One of my friendly staff suggested I write about Seasonal Affective Disorder, commonly known as SAD because she had received several calls about it over the last few days. SAD is a topic I have not written about but a concern in our area, so here goes. SAD is a type of depression that occurs during certain times of the year. Most often, people experience it in the fall and winter months when the days become shorter and there is less natural sunlight. SAD can affect anyone, but it is more common in those who live in areas far from the equator, like North Dakota, where daylight hours are more drastically reduced during winter . Understanding the background of this disorder and its signs and symptoms can help those affected find relief and manage their condition. The exact causes of SAD are not fully understood, but scientists believe it is linked to changes in sunlight exposure. During the fall and winter months, reduced sunlight can disrupt the body’s internal clock, also known as the circadian rhythm. This disruption can lead to fatigue, sadness, and a lack of motivation. Another factor is the brain chemical serotonin, which helps regulate mood. Reduced sunlight may cause a drop in serotonin levels, contributing to feelings of depression. Additionally, the change in light can affect the body’s production of melatonin, a hormone that helps regulate sleep. Increased melatonin levels during the darker months can make people feel sluggish and tired. Genetics and family history may also play a role. If someone has a family member with depression or SAD, they may be more likely to develop the disorder themselves. Seasonal Affective Disorder can manifest in several ways, depending on the individual. The symptoms can range from mild to severe, interfering with daily life and relationships. While many of the symptoms overlap with those of major depression, they are linked to a specific time of the year. Common Symptoms Include: • People with SAD often report persistent sadness or a low mood, which can be especially noticeable during the fall and winter months when the disorder is most prevalent. • Hobbies or activities that once brought joy may no longer seem enjoyable or worth pursuing. • Fatigue and lack of energy are hallmark symptoms of SAD. Even after a full night’s sleep, individuals may feel exhausted and have difficulty performing daily tasks. • People with SAD may experience oversleeping (hypersomnia) or difficulty staying awake during the day. Others may struggle with insomnia or poor sleep quality. • Many crave carbohydrates or comfort foods, leading to weight gain during winter. • SAD can make it hard to focus on work, school, or personal tasks, further adding to feelings of frustration and helplessness. In severe cases, SAD can lead to deep feelings of despair and may even include thoughts of self-harm or suicide. If these thoughts occur, immediate professional help is critical. Although SAD is most often associated with winter, some individuals experience a less common form of the disorder during the spring and summer months. Known as summer-pattern SAD, this type may include symptoms like insomnia, decreased appetite, anxiety, and restlessness. Several factors increase the likelihood of developing SAD. Women are more likely to be diagnosed with the disorder than men, although men tend to have more severe symptoms when they are affected. Young adults and teenagers are also at higher risk compared to older adults. Living in regions with long winters or frequent cloudy weather, such as northern parts of the U.S., Canada, or northern Europe, can also make SAD more likely. Recognizing the signs of SAD is the first step toward managing the disorder. Left untreated, SAD can significantly impact mental health, relationships, and overall quality of life. Traditional treatment options for SAD include light therapy and medications. Light therapy involves sitting near a special light box that mimics natural sunlight. This helps regulate the body’s internal clock and improve mood. Light therapy is usually done in the morning for 20-30 minutes daily. Practitioners may also prescribe antidepressant medications, such as selective serotonin reuptake inhibitors (SSRIs). These help balance brain chemicals linked to mood. Sometimes, counseling or cognitive behavioral therapy (CBT) is recommended to help patients manage negative thoughts and develop healthier habits. Other non-conventional treatment options include exercise. Regular physical activity, especially outdoors, can improve mood by increasing the release of feel-good chemicals like endorphins. Even on cloudy days, getting outside for a walk or jog can provide exposure to natural light, which may help regulate your body’s internal clock. If exercise is not your thing yet, you would still like to benefit from an increase in endorphins. A compounded medication like low-dose naltrexone can trick the body into making more of these energy-producing chemicals. Another approach is dietary changes and supplements. Foods rich in omega-3 fatty acids, like salmon and walnuts, may help improve mood. When these foods are unavailable, taking omega-3 fish oil in supplement form is always an option. One of my favorite supplements is vitamin D , which is often recommended since lower levels of this vitamin are common during the winter and can affect mood. Where we live in relation to the potency of the sun and our inability to get enough sun with the cold weather makes vitamin D a necessity in the winter month of ND. Remember that omega-3 and vitamin D levels can be easily tested to ensure you are at an optimal level. Mindfulness and meditation practices can also help. Techniques like deep breathing, yoga, and guided meditations reduce stress and promote relaxation, helping to counter the anxiety or sadness that can accompany SAD. Some people find relief through aromatherapy. Essential oils like lavender and citrus are believed to boost mood and energy. Using a diffuser or adding a few drops to a bath can provide calming effects. While not replacements for professional care, these alternative treatments can complement traditional approaches and provide additional relief. Anyone experiencing severe symptoms should consult a healthcare professional to find the right balance of treatments. While the changing seasons can be beautiful, they can also bring challenges. Knowing how they affect your mental health can make all the difference in facing those challenges head-on. Stop by or call the pharmacy for more information on options to help deal with SAD during winter. Please visit my website at www.irsfeldpharmacy.com to find this and other archived articles in the blog section. Until next time, be vigilant about your health!!
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